p53: The Gene that Cracked the Cancer Code, Sue Armstrong

This is a good survey of the study of the p53 gene: one gene which turns out to have quite a bit influence on whether or not cancer develops in the body. It features some science, some history, some characters, and generally clear explanations of exactly how the science all works. It’s evident that it’s written by a journalist and not an expert, but that’s usually the perfect level for a casual reader anyway.

Now, if you don’t find cancer and how it progresses interesting, this will probably be lost on you. But if you have any interest, the background covered here is quite important to understanding cancer as a disease. It covers stuff like the “two hits” theory, why some children can be born with cancer, etc, etc. Enjoyable might be the wrong word for it, but I found it easy to read and informative.

Rating: 4/5

Natural Histories, Brett Westwood, Stephen Moss

If you’re pretty well versed in natural history and biology, this book won’t hold many surprises for you — though it might have a few titbits you’re unaware of. It’s certainly very readable, and the cover design is pretty darn awesome. And slightly creepy, in that way which things of nature can be. (I mean, have you ever seen a rabbit’s skull? Erk.)

It might be more enjoyable if read alongside or as a recap for the radio programme it was based on. As it is, it seems to hop around the animal kingdom rather randomly.

This may sound like damning with faint praise, but it’s just that the book isn’t really a good fit for me. And it did hold a few surprises.

Rating: 3/5

I Contain Multitudes, Ed Yong

If you’ve already read books like Martin Blaser’s Missing Microbes, a lot of this info won’t be new to you. However, Ed Yong’s enthusiasm and wider range — dipping into the microbes of other animals and even insects — is a joy. He also provides a counterpoint to some of Blaser’s more hysterical ideas about the loss of microbes. He agrees that microbes are important, and that our relationships with them are complex. But he doesn’t accept that we’re totally doomed. There’s tons of research into repopulating our guts with beneficial microbes, prebiotics and probiotics. No doubt things are in the pipeline which will make a difference.

Yong is significantly less hopeful about the potential of procedures like faecal transplants — though the results have been encouraging in cases of C. difficile infections, the potential for treating inflammatory bowel disease seems more limited. It’s not impossible that a refined version of faecal transplants can help to rebalance the irritated and inflamed gut systems of people who suffer from inflammatory bowel diseases… but so far, the data isn’t there.

With his enthusiasm and interest, Yong makes me want to hurry the heck up, get my biology degree, and get stuck into researching on exactly these topics. One thing is for sure: our microbiome is incredibly important, and we need more research. Our gut microbes can affect our overall health in so many ways — mental health included — that I foresee a lot more time being spent on this in labs in the near future. And I hope I’ll be one of the people working in one of those labs.

If you don’t know much about microbes, fear not: Yong’s writing is clear and accessible, with no technobabble. I think this book would be totally accessible to anyone with an interest.

Rating: 4/5