I really enjoyed Harkup’s book on Agatha Christie’s use of poisons in her plots — I wasn’t a Christie fan, but the book gave me a whole new appreciation for her work — so I jumped on this the minute I saw it. It begins largely as a biography of Mary Shelley, to be quite frank; there’s very little science for at least half the book, and there’s rather too much re-describing the plot. I get that the actual book isn’t familiar to everyone, but this is billed as pop-sci, not Sparknotes.
Nonetheless, when she does eventually get down to it, it’s fascinating to hear about the science of the day and what Shelley may have been aware of. Calling it the first science fiction book sounds a bit odd, because it’s not really the aesthetic you think of — but Shelley did research and was careful to reflect the science of the day. Maybe it’s not hard SF, and there’s much that seems unlikely now, but it’s still based on the understanding of science that she could possibly have been aware of.
Still a bit too biographical, overall: I believe seeing books in their context is important, but Mary Shelley’s parentage and miscarriages were less than necessary to the overall narrative.