Tag: science

Review – The Good Virus

Posted July 31, 2023 by Nicky in Reviews / 0 Comments

Cover of The Good Virus by Tom IrelandThe Good Virus, Tom Ireland

This is one of those popular science books that got me excited by teaching me new things — something that you wouldn’t think is easy when it comes to things like viruses, which I’m studying during my MSc at LSHTM. The “good viruses” of the title are bacteriophages, though: viruses that specifically target bacteria as their natural hosts, and surprisingly little is sad about those when you’re studying viruses in general, despite the fact that — as Ireland makes clear — they’re absolutely ubiquitous. If anything rules the world by sheer numbers, it’s bacteriophages, and they’re absolutely everywhere, from the icecaps to the deep ocean to the human body.

It’s likely that Ireland is a little hyperbolic at times here about the potentials of bacteriophages, though he does sound a note of caution here and there about his own enthusiasm. But it’s also true that bacteriophages offer us some answers to knotty problems, like antimicrobial resistance, and we’d be stupid to keep turning away. I had no idea that bacteriophages were being used to treat bacterial infections in clinics in places like Georgia, and I had no idea that “the West” was so pathetically behind and completely unable to legislate in ways that would make clinical trials possible. It’s exciting, and vital, and I have so many questions about why we’re not in a hurry to do more.

If you’re in my position, where you study this stuff, then obviously this book — absolutely riveting as I found it — isn’t the end: you’ll need to read papers, ask further questions, and maybe get in the lab. But as a starting point, it’s a good read, informative and enthusiastic, and full of titbits I couldn’t wait to share with… well. More or less everyone who stayed within earshot for long enough, actually.

This is the best kind of popular science, shining a light on something that is wrongly obscure, and it has plenty of resources in the footnotes to guide you to where the info comes from. (That said, more footnotes would’ve been good. I wasn’t always happy with statements that didn’t have references.)

So glad I picked this up.

Rating: 5/5

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Review – Pathogenesis

Posted May 29, 2023 by Nicky in Reviews / 1 Comment

Cover of Pathogenesis by Jonathan KennedyPathogenesis, Jonathan Kennedy

Pathogenesis was less absorbing for me than I’d hoped; I love non-fiction about diseases, even though I’m already studying for my MSc in the subject and thus most of it is not new to me. Still, often there are titbits I didn’t know, and that seemed like it was going to prove true here too when I read the introduction: did you know that viral genes are involved in the formation of the mammalian placenta?

But overall, the rest of it was much less scientific, less based on… well… pathogenesis, and much more about history. How diseases affected armies and governments, and how changes like capitalism (of which the author seems to be a huge fan) changed the approach to public health. Which is to say, created a demand for it, since there was no such thing under feudalism.

For someone who is interested in the history of infectious diseases in relation to humanity, this is probably still fascinating. For me, it was just a bit to starboard of my real interests, and I found it far too simplistic in discussing how diseases work. (Plus, there was definitely a lot more room to consider the impacts of the current pandemic and what it means for the future. Consider the impact on the treatment of tuberculosis, for example — deeply negative.)

It was alright, but not what I wanted, ultimately.

Rating: 3/5

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Review – The Premonitions Bureau

Posted May 3, 2023 by Nicky in Reviews / 0 Comments

Cover of The Premonitions Bureau by Sam KnightThe Premonitions Bureau, Sam Knight

The study of things like psychic powers and premonitions is always fascinating. There’s a sense that so many of us want to believe in this sort of thing — the way the human brain insists that there must be a pattern behind circumstances. One can be fairly intellectually sure that there’s no such thing as precognition per se, and yet find it a little freaky that (say) a young girl would dream of her school being swallowed up by black stuff a couple of nights before she dies in the Aberfan disaster…

This book is all about digging into that, mostly through looking at the investigations and interests of John Barker, a British psychiatrist who tried to gather up premonitions and test them scientifically. He was sometimes a bit too credible, a bit too inclined to influence the data — but then, two of his clairvoyants (percipients, as he called them) predicted his death fairly accurately, and had a number of other surprisingly specific hits (such as predicting a train derailment).

The book mostly follows Barker, along with a few of his colleagues, trying to understand his attempts to study premonitions, and why he was so fascinated by the subject. Knight doesn’t attempt to come to any conclusions, just presents the facts as best as they can be known — though of course there’s always a chance someone massaged the facts to make a better story, whether it was Barker, one of his colleagues, or Knight himself.

There’s quite a bit of detail on the Aberfan disaster in the first 50 pages, by the way, which hit me where I live. If that disaster is particularly evocative for you, then read with care.

Rating: 4/5

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Review – Models of the Mind

Posted April 5, 2023 by Nicky in Reviews / 0 Comments

Cover of Models of the Mind by Grace LindsayModels of the Mind: How Physics, Engineering and Mathematics Have Shaped Our Understanding of the Brain, Grace Lindsay

I’m probably slightly misquoting, but there’s a bit in Dorothy L. Sayers’ Clouds of Witness where Peter’s sister is explaining things to him, and asks him if she isn’t making his head hurt. “Damnably, but I like it. Go on,” Peter says. I felt kind of that way, when reading this — I wasn’t always 100% understanding what was going on, for sure, but I was intrigued and I wanted to read more. Each chapter helped build my understanding up a little more, too: I found it was well-written in that way, even if math really isn’t my thing.

I doubt I’ve retained a great deal of the information, sadly, but it was nonetheless an enjoyable reading experience. The brain is so complex and so fascinating, and Lindsay tries to show how mathematics has been able to illuminate parts of how it works — where squishy biologists like myself might shrug and say it’s too complex. (Maybe that’s just me.)

Most likely math can’t answer all the questions on its own, but Lindsay makes it clear that it’s offered some useful insights and paths to go down.

Rating: 4/5

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Review – A Taste for Poison

Posted April 2, 2023 by Nicky in Reviews / 0 Comments

Cover of A Taste for Poison by Neil BradburyA Taste for Poison, Neil Bradbury

This book didn’t start quite where I expected it to, with the most conventional poisons — arsenic or cyanide or even digitalis. It began with insulin, which was an interesting way to approach the topic, and that gave it a certain amount of freshness. Each poison is illustrated with two or three stories about how it’s been used by someone or other, historically, and how they were caught (of course, cases where no one was caught are harder to prove).

It talks a little about how each poison works — not in exhaustive detail, but enough to give you a pretty good layperson’s understanding of why it should prove a poison.

It’s interesting how often doctors and medical professionals are the culprits in these stories. It makes sense — access to the poisons, and trust from patients — but it’s a little disheartening to read, actually!

Rating: 3/5

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Review – Splitting: The Inside Story on Headaches

Posted January 10, 2023 by Nicky in Reviews / 7 Comments

Cover of Headaches by Amanda EllisonSplitting: The Inside Story on Headaches, Amanda Ellison

This is very much a book for a layperson, and I sometimes worry about the author being overly glib or just not thinking things through. At one point, for example, it states that antibiotics are “not very effective” against viruses. The substances commonly thought of as antibiotics — penicillin, streptomycin, etc — are of course actually antibacterials, and are not at all effective against viruses, and it’s irresponsible to suggest that they are at all effective in that situation, given that they’re completely pointless.

If you’re going to refer to antivirals as “antibiotics” (which some people might do, arguing that “anti-biotic” means “anti-life” — assuming you believe that viruses are alive), then it’s irresponsible in the other direction to suggest that they’re not very effective. It might lead to someone not taking antivirals when they should. I know this sounds like an extremely minor point in a book unrelated to infectious disease, but it’s really important, and a good scientist should not cut this kind of corner, even (or perhaps especially) when communicating to laypeople.

When it comes to discussing neurotransmitters and so on, the author is fairly precise… so far as I can tell, being more interested in infectious disease than human biology for the sake of human biology. Given her carelessness about other things, though, it does leave me with doubts.

I did appreciate the chapter on tension headaches, which I’m prone to. There’s even an interesting point about the fact that stomach ulcers generating histamine, which — given a stomach ulcer is one of the potential causes of some of my health issues, and given my high levels of stress — is worth exploring. But, by and large, I’m not impressed with this book. Writing for laypeople should not mean being cavalier about facts.

Rating: 2/5

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Review – Immune

Posted January 24, 2022 by Nicky in Reviews / 0 Comments

Cover of Immune by Philipp DettmerImmune: A Journey into the Mysterious System That Keeps You Alive, Philipp Dettmer

Immune: A Journey into the Mysterious System That Keeps You Alive is a beautifully illustrated book that aims to make a complex system clear and accessible for a reader who is pretty much new to the topic (maybe you’ve got a GCSE in biology or something, but that was a long time ago). It’s chatty and informal and uses a lot of analogies to make things simple to remember, and it’s often irreverent. (At one point it compares the shape of antibodies to crabs, and then refers to their “butts”, leading to this immortal phrase: “The pincers are for enemies, the cute butts for friends.”)

The author is clearly absolutely bowled over by the beautiful dance that is the human immune system, the various clever ways it protects us and regulates itself, and that shines through in pretty much every chapter. He’s explaining things and being really clear and going into detail because he wants you to see how gorgeous it all is.

Now I already appreciated that (everyone close to me flashes back to my impassioned glee about the membrane attack complex), so it wasn’t new to me — but still, his enthusiasm made me smile. It’s not bad as a revision session for me either, and even though I’ve studied human biology and infectious diseases quite a bit, there were still one or two surprises for me. Just wait until you get to the bit about NETs. Wow.

Throughout, he mentions the SARS-CoV-2 pandemic and how some of this information applies to that; it’s not a book about the pandemic, but it can definitely help you understand the pandemic. It also explains why vaccination works, and why there’s no meaningful difference between “natural” immunity and that gained through vaccination — your cells go through exactly the same process. It’s all pretty great, and I’d recommend it to people at all levels of ability. It’s also just beautiful, with a ton of diagrams that make things really clear.

Rating: 5/5

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Review – Humankind

Posted January 22, 2022 by Nicky in Reviews / 0 Comments

Cover of Human kind: A Hopeful History by Rutger BremanHumankind, Rutger Bregman

This was a really quick read which I found myself really enjoying. It’s a profoundly optimistic book, arguing that humans are generally inclined toward cooperation and care for one another, and highlighting the pitfalls (and manipulations inherent in) certain famous studies that people have relied on for a rather pessimistic view of humanity. We’re talking Stanley Milgram’s electric shock experiments, Philip Zimbardo’s Stanford prison experiment, and Muzafer Sherif’s Robbers Cave experiment — “I was just following orders”, “power will inevitably be abused”, “kids will go full Lord of the Flies if left alone”.

The criticisms of these are known elsewhere, based on methodology and skewed reporting (the experimenters put heavy pressure on the subjects of the electric shock studies, and many of the subjects didn’t actually believe there was anyone being shocked; the prison guards were heavily coached to behave the way they did by Zimbardo himself and a hand-picked guard, plus the guy who allegedly went crazy just wanted to get out of there and acted it; the kids were manipulated into fighting, but actually tended toward cooperation and reconciliation when left alone), and Bregman lays out the criticisms well. He’s not some lone voice in the wilderness here: if you read around, there are plenty of critiques of those old experiments, and attempts to reproduce the results have failed or had markedly less success.

He also picks apart the very well known “bystander syndrome”, by pointing out that one of the people who didn’t act in the famous case of Kitty Genovese’s murder was terrified of being found out for being queer, and instead ran to find someone else… who ran out of her home immediately and held Genovese in her arms until an ambulance arrived. Kitty Genovese didn’t die alone, and witnesses did call the police, who gave the reports low priority as the witnesses didn’t know what they’d witnessed was a serious attack.

At the same time, Bregman does acknowledge that these results were obtained and can be under some circumstances. It would be wrong to characterise his point as being that humans are always going to be good. In fact, he points out situations that bring out the worst in us, mostly (in his view) in line with the mismatch hypothesis: humans as a species didn’t evolve for this modern, technological world with crowded cities, neighbours you don’t know, etc.

His answer is not that we necessarily need to go back to pre-city ways of living. In fact, many of his suggestions are about bringing out the best in ourselves in the world that we have, with individual-level suggestions about trust, avoiding the news, not getting swept up in the latest outrage, etc.

I think he’s an optimist and an idealist, and his argument that we can’t be cooperative and good to one another without trust is difficult to refute in a world where suspicion seems like the best option. His most realistic suggestion is to live, as an individual, as trustfully as possible, and reach for the cooperative solution as much as you can. To do good openly, and spread that goodness by example.

Much of what he says is what I’d like to believe, and much of what he suggests is how I already choose to act, so of course the book plays into my bias. Still, I think it’s well-written, spiced with just the right anecdotes to make his point, and a good (and surprisingly quick) read — I tore through it. If he’s wrong, well, I’d like him to be right, and I think little harm will come from believing that he’s right.

Rating: 5/5

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Review – Diagnosis

Posted November 28, 2021 by Nicky in Reviews / 0 Comments

Cover of Diagnosis by Lisa SandersDiagnosis: Solving the Most Baffling Medical Mysteries, Lisa Sanders

Each chapter of this book is a little précis of a case, with the key details you need for figuring out what exactly happened, should you have the knowledge and experience — and of course some flavour text, because where would we be without knowing that a young girl was an athlete, or a straight-A student, etc, etc? The stories are pretty short, each illustrating a medical mystery (to one degree or another — some of these I guessed, and others I’d have no idea about).

It’s very light, of course, but for a layperson it’s perfect, and illustrates some of the weirdnesses of bodies and diseases. I found that it actually made me a little anxious, partly because of the trappings of characterisation and life situations that were given for flavour — it makes it all too easy for me to imagine the same situation happening to me and my loved ones. Nonetheless, I powered through, and thought it was pretty interesting and well-written for what it is.

Rating: 4/5

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Review – Breaking the Chains of Gravity

Posted November 15, 2021 by Nicky in Reviews / 0 Comments

Cover of Breaking The Chains of Gravity by Amy Shira TeitelBreaking the Chains of Gravity: The Story of Spaceflight Before NASA, Amy Shira Teitel

The problem with the early history of missiles, which came to enable space exploration, is apparently that it’s mostly about Nazis. Wernher von Braun ends up being the main focus of the narrative because he was deeply involved in rocketry all along, and unfortunately the author takes a tone that sees him as a visionary, nobly defending his precious and important project…….. by becoming a Nazi, accepting slave labour to assist in building it, and — she doesn’t mention this, somehow, mysteriously — being accused along the way of actively helping to torture prisoners.

Many ordinary people got caught up in the Nazi party, but most of them wouldn’t try to defend themselves by claiming their project was too important to abandon. Hiding behind the importance of his project is what skeeves me out more than anything with von Braun — and what skeeves me out with Amy Shira Teitel is how little she bothers to grapple with that fact. You’re writing about a Nazi, and that requires careful handling, and for the love of God you should not be suggesting that the ends (protection of the missile programme) might justify the means (the brutal use and torture of prisoners), even inadvertently. You should be so careful about that that the accusation could never arise.

Amy Shira Teitel… was not. Her enthusiasm for rocketry is clear, but her judgement is sorely in question. In addition, because I could not possibly care less about fucking Nazis, I found a lot of the book difficult to read and frankly tedious. Oh! It’s another explanation of how clever von Braun is and how carefully he protected his team of scientists from dying in the war! What a shame he couldn’t do anything about the torture and deaths that facilitated his programme.

Uggghhh.

Rating: 2/5

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